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A-77003

CAT: 0804-HY-19135Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19135Size:1 Each
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Description
A-77003 is an inhibitor for HIV protease, with IC50 of 0.1 to 0.2 μg/ml, for HIV-1 and HIV-2 protease. A-77003 exhibits high levels of antiretroviral activity and low cytotoxicity in vitro[1].
CAS Number
134878-17-4
UNSPSC
12352005
Target
HIV Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/a-77003.html
Smiles
O[C@@H]([C@H]([C@@H](NC([C@@H](NC(N(C)CC1=NC=CC=C1)=O)C(C)C)=O)CC2=CC=CC=C2)O)[C@@H](NC([C@@H](NC(N(C)CC3=NC=CC=C3)=O)C(C)C)=O)CC4=CC=CC=C4
Molecular Formula
C44H58N8O6
Molecular Weight
794.98
References & Citations
[1]Reedijk M, et al. Safety, pharmacokinetics, and antiviral activity of A77003, a C2 symmetry-based human immunodeficiency virus protease inhibitor. Antimicrob Agents Chemother. 1995 Jul;39 (7) :1559-64.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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