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Poloxime

CAT: 0804-HY-77195-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-77195-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.
CAS Number
17302-61-3
UNSPSC
12352211
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Poloxime.html
Purity
95.0
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)
Smiles
CC1=CC(C(C(C)C)=C/C1=N\O)=O
Molecular Formula
C10H13NO2
Molecular Weight
179.22
References & Citations
[1]Liu M, et al. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorg Med Chem Lett. 2015 Feb 1;25 (3) :431-4.|[2]Yin Z, et al. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic. ACS Chem Biol. 2013 Feb 15;8 (2) :303-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLK1

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Alternative Products

CatalogName
B3609-5Poloxime
A12145-25Poloxime 25mg
A12145-2Poloxime 2mg
A12145-1000Poloxime 1g
A12145-100Poloxime 100mg
A12145-10Poloxime 10mg
A12145-5Poloxime 5mg
A12145-500Poloxime 500mg
A12145-50Poloxime 50mg
A12145-10mM-DPoloxime 10mM * 1mL in DMSO

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