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BHA536

CAT: 0804-HY-164462Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164462Size:1 Each
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Description
BHA536 is an orally active selective inhibitor for PKCα/β and NF-kB signaling pathway. BHA536 inhibits the proliferation of CD79-mutated ABC DLBCL cell, arrests cell cycle at G1 phase, and induces apoptosis in TMD8 cell. BHA536 exhibits antitumor efficacy in mice[1].
CAS Number
919992-85-1
UNSPSC
12352005
Target
Apoptosis; NF-κB; PKC
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; NF-κB; TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bha536.html
Smiles
CN(C)CC1=CC2=C(C=C1)C=CC(Cl)=C2C3=C(C4=CNC5=C4C=CC=C5OCCOCCOC)C(NC3=O)=O
Molecular Formula
C30H30ClN3O5
Molecular Weight
548.03
References & Citations
[1]Naylor TL, et al., Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas. Cancer Res. 2011 Apr 1;71 (7) :2643-53.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19239017-01BHA536

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