Anti-Eotaxin Antibody

• Description:

  Rabbit Polyclonal Antibody specific to Eotaxin (CT)

• Product Name Alternative:

  C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11

• Gene Name:

  CCL11

• Gene ID:

  6356

• NCBI Gene ID:

  CCL11

• UniProt:

  P51671

• Accession Number:

  NP_002977.1

• Cellular Locus:

  Secreted

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Peptide corresponding to aa 83-97 of human eotaxin.

• Target Antigen:

  Eotaxin

• Target:

  Eotaxin

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Type:

  Antibody

• Applications:

  ELISA, WB, ICC, IF

• Field of Research:

  Infectious Disease

• Purification Method:

  Purified by peptide immuno-affinity chromatography

• Concentration:

  Lot Specific

• Dilution:

  Dilute in PBS or medium which is identical to that used in the assay system.

• Format:

  Purified

• Form:

  Liquid

• Buffer:

  Phosphate Buffered Saline

• Function:

  In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions (PubMed:8597956). Binds to CCR3 (PubMed:8631813). {PubMed:8597956, PubMed:8631813}.

• Additionnal Information:

  Immunoblotting: use at 1:500-1:1,000 dilution.
  
  Positive control: Native and recombi- nant protein.

• Storage Conditions:

  This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

• Specificity:

  This antibody recognizes the monomeric (9 kD) and dimeric (18 kD) forms of human eotaxin

• Formulation:

  PBS, pH 7.4.

• Buffer pH:

  pH 7.4

• Target Background:

  Chemokines play a key role in inflammation. The CC chemokine eotaxin is a potent and specific eosinophil chemoattractant that is expressed by a variety of cell types in certain inflammatory conditions. Some G-protein coupled chemokine receptors are also utilized as virus coreceptors for fusion and infection of cells. The eotaxin receptor CCR3 is required for HIV-1 entry into target cells such as microglia, and eotaxin inhibits infection by HIV-1.

• CAS Number:

  9007-83-4