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Sarizotan

CAT: 0804-HY-100820-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100820-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively[1].
CAS Number
351862-32-3
Product Name Alternative
EMD 128130
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sarizotan.html
Purity
98.23
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C2=CN=CC(CNC[C@H]3CCC4=CC=CC=C4O3)=C2)C=C1
Molecular Formula
C22H21FN2O
Molecular Weight
348.41
References & Citations
[1]G D Bartoszyk, et al. Sarizotan, a Serotonin 5-HT1A Receptor Agonist and Dopamine Receptor Ligand. J Neural Transm (Vienna) . 2004 Feb;111 (2) :113-26.|[2]C Marin, et al. Local Administration of Sarizotan Into the Subthalamic Nucleus Attenuates Levodopa-Induced Dyskinesias in 6-OHDA-lesioned Rats. Psychopharmacology (Berl) . 2009 Jun;204 (2) :241-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT1 Receptor; D2 Receptor; D3 Receptor; D4 Receptor; lactoferrin; mLAG-3; MUC2; MUC3; Prostaglandin D Synthase; α-1 microglobulin

Alternative Products

CatalogName
BA5004-5Sarizotan
T70044-01Sarizotan HCl
AR-S09956-01Sarizotan DiHCl
BUP03296-01Sarizotan 2HCl
AR-S09958-01Ent-Sarizotan DiHCl
AR-S09955-01Sarizotan Impurity 3
AR-S09957-01N-Nitroso Sarizotan
AR-S09953-01Sarizotan Impurity 1
AR-S09954-01Sarizotan Impurity 2

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