Products for Research Use Only
RegisterLogin

Oxypeucedanin

CAT: 0804-HY-N0747-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N0747-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Oxypeucedanin is a furanocoumarin derivative found in Angelica dahurica. Oxypeucedanin is an orally active PI3K/AKT/NF-κB, MAPK, and ROS inhibitor. Oxypeucedanin induces cell cycle arrest and apoptosis. Oxypeucedanin inhibits hKv1.5 channel currents (IC50: 76 nM) . Oxypeucedanin exhibits anticancer, anti-inflammatory, antioxidant and antiarrhythmic activities[1][2][3][4][5].
CAS Number
737-52-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; Apoptosis; COX; ERK; JNK; NF-κB; NO Synthase; p38 MAPK; PI3K; Potassium Channel
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/oxypeucedanin.html
Purity
99.50
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1(C)C(O1)COC2=C(C=CO3)C3=CC(O4)=C2C=CC4=O
Molecular Formula
C16H14O5
Molecular Weight
286.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Eun JS, et al. Effects of oxypeucedanin on hKv1.5 and action potential duration. Biol Pharm Bull. 2005 Apr;28 (4) :657-60.|[2]Kang TJ, et al. Anti-tumor activity of oxypeucedanin from Ostericum koreanum against human prostate carcinoma DU145 cells. Acta Oncol. 2009;48 (6) :895-900.|[3]Du L, et al. Oxypeucedanin relieves LPS-induced acute lung injury by inhibiting the inflammation and maintaining the integrity of the lung air-blood barrier. Aging (Albany NY) . 2022 Aug 18;14 (16) :6626-6641.|[4]Liu M, et al. Oxypeucedanin hydrate alleviates rheumatoid arthritis by inhibiting the TLR4-MD2/NF-κB/MAPK signaling axis. Acta Biochim Biophys Sin (Shanghai) . 2024 May 11;56 (12) :1789-1801.|[5]Zheng MC, et al. Preclinical Pharmacokinetics and Bioavailability of Oxypeucedanin in Rats after Single Intravenous and Oral Administration. Molecules. 2022 Jun 2;27 (11) :3570.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
BA2966-5Oxypeucedanin
XO167943-01(-) -Oxypeucedanin
XO163800Oxypeucedanin methanolate
300738Oxypeucedanin hydrate
BUP00400-01(-) -Oxypeucedanin hydrate
GTR19221850-01Iso-oxypeucedanin
T75620-01(+) -Oxypeucedanin methanolate

Popular Products