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Chelidonine

CAT: 0804-HY-N2369-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2369-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity[1][2][3].
CAS Number
476-32-4
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
Apoptosis; Influenza Virus
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/chelidonine.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1[C@@]2([H])[C@@]([C@H](CC3=C2C=C4C(OCO4)=C3)O)([H])C5=C(C6=C(OCO6)C=C5)C1
Molecular Formula
C20H19NO5
Molecular Weight
353.37
Precautions
H302+H312+H332
References & Citations
[1]Lee YK, et al. Chelidonine Induces Caspase-Dependent and Caspase-Independent Cell Death through G2/M Arrest in the T98G Human Glioblastoma Cell Line. Evid Based Complement Alternat Med. 2019 May 26;2019:6318179.|[2]Isolani ME, et al. The in vivo effect of chelidonine on the stem cell system of planarians. Eur J Pharmacol. 2012 Jul 5;686 (1-3) :1-7.|[3]Hammerová J, et al. Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status. J Dermatol Sci. 2011 Apr;62 (1) :22-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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