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Chelidonine

CAT: 0931-T5S0055-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T5S0055-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
476-32-4
Target
Influenza Virus, Apoptosis
Related Pathways
Microbiology/Virology, Apoptosis
Purity
0.9961
Bioactivity
1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2.
Smiles
[H][C@]12[C@@H](O)Cc3cc4OCOc4cc3[C@@]1([H])N(C)Cc1c3OCOc3ccc21
Molecular Formula
C20H19NO5
Molecular Weight
353.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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