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Tadalafil (Standard)

CAT: 0804-HY-90009AR-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-90009AR-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tadalafil (Standard) is the analytical standard of Tadalafil. This product is intended for research and analytical applications. Tadalafil (IC-351) is a PDE5 inhibitor with an IC50 value of 1.8 nM.
CAS Number
171596-29-5
Product Name Alternative
IC-351 (Standard)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Phosphodiesterase (PDE) ; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/tadalafil-standard.html
Purity
99.97
Solubility
DMSO : ≥ 52 mg/mL
Smiles
O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O
Molecular Formula
C22H19N3O4
Molecular Weight
389.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Blount MA, et al. Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation. Mol Pharmacol. 2004 Jul;66 (1) :144-52.|[2]Yang Y, et al. Effect of acute tadalafil on sperm motility and acrosome reaction: in vitro and in vivo studies. Andrologia. 2013 Apr 14. [Epub ahead of print]|[3]Mostafa ME, et al. Effect of Chronic Low-dose Tadalafil on Penile Cavernous Tissues in Diabetic Rats. Urology. 2013 Jun;81 (6) :1253-60.
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched

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