Dorsomorphin

• Description :

  Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP) . Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599) [1][2].

• Product Name Alternative :

  Compound C; BML-275

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  AMPK; Autophagy; Organoid; TGF-β Receptor

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Epigenetics; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dorsomorphin.html

• Purity :

  99.91

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl)

• Smiles :

  C12=C(C3=CC=NC=C3)C=NN1C=C(C4=CC=C(OCCN5CCCCC5)C=C4)C=N2

• Molecular Formula :

  C24H25N5O

• Molecular Weight :

  399.49

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zhou G, et al. Role of AMP-activated protein kinase in mechanism of action. J Clin Invest. 2001 Oct;108 (8) :1167-74.|[2]Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7 (9) :e45845.|[3]Yu PB, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan;4 (1) :33-41.|[4]Kim YM, et al. Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo. Atherosclerosis. 2011 Nov;219 (1) :57-64.|[5]Guo Y, et al. AMPK inhibition blocks ROS-NFκB signaling and attenuates endotoxemia-induced liver injury. PLoS One. 2014 Jan 24;9 (1) :e86881.|[6]Zhang Y, et al. Urolithin A suppresses glucolipotoxicity-induced ER stress and TXNIP/NLRP3/IL-1β inflammation signal in pancreatic β cells by regulating AMPK and autophagy. Phytomedicine. 2021 Dec;93:153741.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ALK2; ALK3; ALK6; AMPK

• Citation 01 :

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• CAS Number :

  [866405-64-3]