Kv1.8 rabbit pAb

CAT: 0855-ES20686-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES20686-01Size:50 µL

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Background

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s) . This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA

Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA

UniProt

Q16322

Swiss Prot

Q16322

Reactivity

Human; Rat; Mouse

Immunogen

Synthetic Peptide of Kv1.8 AA range: 194-244

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF

Concentration

1 mg/ml

Dilution

WB 1:1000-2000, IHC 1:100-200

Molecular Weight

58kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

58kD

Fragment

IgG

Subcellular Location

Membrane ; Multi-pass membrane protein .

Other Product Names

Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8)

Gene ID (Human)

3744

UniProtKB · Q16322

Potassium voltage-gated channel subfamily A member 10

KCA10_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q16322
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: KCNA10
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: —

Protein keywords

PTM

GlycoproteinLipoproteinPalmitate

Molecular function

Ion channelPotassium channelVoltage-gated channel

Biological process

Ion transportPotassium transportTransport

Cellular component

Membrane

Ligand

Potassium

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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Alternative Products

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E47R16866	Kv1.8 Rabbit pAb
DL95748A-01	Rabbit anti-Kv1.8 Antibody
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GTR18049703-01	Kv1.8 Rabbit pAb Antibody
TA338556	Kv1.8 (KCNA10) Rabbit Polyclonal Antibody
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GTR18482085	Kv1.8 Rabbit Polyclonal Antibody (BF750)
GTR18482084	Kv1.8 Rabbit Polyclonal Antibody (PerCP)