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CCT018159

CAT: 0804-HY-110042-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110042-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC50s of 3.2 and 6.6 µM for human Hsp90β and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis[1].
CAS Number
171009-07-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; HSP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cct018159.html
Purity
99.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CC3=C(OCCO3)C=C2)C(C4=CC(CC)=C(O)C=C4O)=NN1
Molecular Formula
C20H20N2O4
Molecular Weight
352.38
Precautions
H302, H315, H319
References & Citations
[1]Swee Y Sharp, et al. In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Res. 2007 Mar 1;67 (5) :2206-16.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90

Alternative Products

CatalogName
MBS5802284CCT018159
WGA00907-01HSP90 Inhibitor, CCT018159

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