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Oteseconazole (Standard)

CAT: 0804-HY-17643R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17643R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oteseconazole (Standard) is the analytical standard of Oteseconazole. This product is intended for research and analytical applications. Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes[1][2].
CAS Number
1340593-59-0
Product Name Alternative
VT-1161 (Standard)
UNSPSC
12352005
Target
Cytochrome P450; Fungal; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/oteseconazole-standard.html
Smiles
O[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OCC(F)(F)F)C=C4)C=N3)F
Molecular Formula
C23H16F7N5O2
Molecular Weight
527.39
References & Citations
[1]Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58 (12) :7121-7.|[2]Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59 (4) :1992-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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