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Oteseconazole

CAT: 0804-HY-17643-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17643-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes[1][2].
CAS Number
1340593-59-0
Product Name Alternative
VT-1161
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
Cytochrome P450; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/oteseconazole.html
Concentration
10mM
Purity
99.60
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OCC(F)(F)F)C=C4)C=N3)F
Molecular Formula
C23H16F7N5O2
Molecular Weight
527.39
Precautions
H228, H315, H319
References & Citations
[1]Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58 (12) :7121-7.|[2]Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59 (4) :1992-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CYP2C19; CYP2C9; CYP51

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