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(R) -Lisofylline

CAT: 0804-HY-109854A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109854A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Lisofylline ((R) -Lisophylline) is a (R) -enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R) -Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 μM and interrupts IL-12 signaling-mediated STAT4 activation. (R) -Lisofylline has the potential for type 1 diabetes, autoimmune disorders research[1][2].
CAS Number
100324-81-0
Product Name Alternative
(R) -Lisophylline
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-lisofylline.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCCC[C@H](O)C)N(C)C2=C(N(C)C=N2)C1=O
Molecular Formula
C13H20N4O3
Molecular Weight
280.32
References & Citations
[1]Elżbieta Wyska, et al. Physiologically Based Modeling of Lisofylline Pharmacokinetics Following Intravenous Administration in Mice. Eur J Drug Metab Pharmacokinet. 2016 Aug;41 (4) :403-12.|[2]B M Hybertson, et al. Lisofylline Prevents Leak, but Not Neutrophil Accumulation, in Lungs of Rats Given IL-1 Intratracheally. J Appl Physiol (1985) . 1997 Jan;82 (1) :226-32.|[3]J J Bright, et al. Prevention of Experimental Allergic Encephalomyelitis via Inhibition of IL-12 Signaling and IL-12-mediated Th1 Differentiation: An Effect of the Novel Anti-Inflammatory Drug Lisofylline. J Immunol. 1998 Dec 15;161 (12) :7015-22.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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