GEA 857

CAT: 0804-HY-117223Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117223Size:1 Each
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Description
GEA 857 is a structural analog of the Serotonin (HY-B1473A) uptake blocker Alaproclate (HY-164011) . GEA 857 enhances responses induced by muscarinic receptor agonists by inhibiting certain calcium-dependent potassium channels on membranes, a blockade that can enhance or prolong the muscarinic cholinergic effects. GEA 857 can be used in research on neurodegenerative diseases[1].
CAS Number
[120493-42-7]
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gea-857.html
Smiles
N[C@@H](C(C)C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O
Molecular Formula
C15H22ClNO2
Molecular Weight
283.79
References & Citations
[1]Ögren, et al. GEA 857, A Putative Blocker of Potassium Conductance, Enhances Muscarinic Agonist‐Evoked Responses: Dissociation from an Action on 5‐HT Mechanisms. Pharmacology & toxicology 71.2 (1992) : 112-119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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