BI-6901

• Description:

  BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0) . BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1].

• Product Name Alternative:

  TC-1734; ACD3480

• UNSPSC:

  12352005

• Target:

  CCR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/bi-6901.html

• Concentration:

  10mM

• Purity:

  99.94

• Solubility:

  DMSO : 160 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=CC=CC2=C1C=CN2)(N[C@@H](C(N3CCC(C)CC3)=O)CCN4C(C#N)=CC=C4)=O

• Molecular Formula:

  C23H27N5O3S

• Molecular Weight:

  453.56

• References & Citations:

  [1]Asitha Abeywardane, et al. N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett. 2016 Nov 1;26 (21) :5277-5283.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2040401-92-9]