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BI-6901

CAT: 0804-HY-116835-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116835-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0) . BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1].
CAS Number
2040401-92-9
Product Name Alternative
TC-1734; ACD3480
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bi-6901.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : 160 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=CC2=C1C=CN2)(N[C@@H](C(N3CCC(C)CC3)=O)CCN4C(C#N)=CC=C4)=O
Molecular Formula
C23H27N5O3S
Molecular Weight
453.56
References & Citations
[1]Asitha Abeywardane, et al. N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett. 2016 Nov 1;26 (21) :5277-5283.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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