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5'-Guanylic acid

CAT: 0804-HY-N5134-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N5134-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5'-Guanylic acid is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid also causes neuronal cell death at high concentrations[1][2][3].
CAS Number
85-32-5
Product Name Alternative
5'-GMP; 5'-guanosine monophosphate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; iGluR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Guanylic_acid.html
Purity
99.96
Solubility
H2O : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=P(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=C(N)NC3=O)O1)O)O)O
Molecular Formula
C10H14N5O8P
Molecular Weight
363.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Tansutaphanit S, et al. Impact of purine nucleotide on fatty acid metabolism and expression of lipid metabolism-related gene in the liver cell of rainbow trout Oncorhynchus mykiss. Comp Biochem Physiol B Biochem Mol Biol. 2023 Jun-Jul;266:110845.|[2]Almeida RF, et al. Systemic administration of GMP induces anxiolytic-like behavior in rats. Pharmacol Biochem Behav. 2010 Sep;96 (3) :306-11. |[3]Molz S, et al., Guanosine-5'-monophosphate induces cell death in rat hippocampal slices via ionotropic glutamate receptors activation and glutamate uptake inhibition. Neurochem Int. 2009 Dec;55 (7) :703-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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