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Tenuazonic acid

CAT: 0804-HY-N6715-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6715-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer[1][2][3][4][5][6][7].
CAS Number
610-88-8
UNSPSC
12352005
Hazard Statement
H301
Target
Bacterial; Enterovirus; Influenza Virus; Photosystem II
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/tenuazonic-acid.html
Purity
99.58
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N[C@@H]([C@@H](C)CC)C(O)=C1C(C)=O
Molecular Formula
C10H15NO3
Molecular Weight
197.23
Precautions
H301
References & Citations
[1]Zhou B, et al. An evaluation of tenuazonic acid, a potential biobased herbicide in cotton. Pest Manag Sci. 2019 Mar 7.|[2]Chen S, et al. Recent advances in tenuazonic acid as a potential herbicide. Pestic Biochem Physiol. 2017 Nov;143:252-257.|[3]MILLER FA, et al. ANTIVIRAL ACTIVITY OF TENUAZONIC ACID. Nature. 1963 Dec 28;200:1338-9. |[4]Kumari A, et al. Tenuazonic acid-induced mycotoxicosis in an immunosuppressed mouse model and its prophylaxis with cinnamaldehyde. Chemosphere. 2024 Sep;363:142812. |[5]Antony M, et al. Inhibition of mouse skin tumor promotion by tenuazonic acid. Cancer Lett. 1991 Dec 9;61 (1) :21-5.|[6]Yun CS, Motoyama T, Osada H. Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme. Nat Commun. 2015 Oct 27;6:8758.|[7]Gil-Serna J., et al. Encyclopedia of Food Microbiology. MYCOTOXINS | Toxicology. 2014 887–892.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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