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Hypidone (hydrochloride)

CAT: 0804-HY-100769-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100769-01Size:2 mg
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Description
Hypidone hydrochloride (YL0919) is an orally active antidepressant agent with dual activity as a highly seletive 5-HT uptake blocker and an effective 5-HT1A receptor agonist (Ki=0.19 nM) . Hypidone hydrochloride inhibits the uptake of [3H]-5-HT into rat cerebral cortical synaptosomes and HEK293 cells with IC50s of 1.78 nM and 1.93 nM, respectively. Hypidone hydrochloride shows remarkable antidepressant effects in animal models and has the poential for the investigation of depressive disorder[1].
CAS Number
1339058-04-6
Product Name Alternative
YL0919
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hypidone-hydrochloride.html
Purity
99.73
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=C1C=CC=CN1CC2(O)CCN(CC3=CC=CC=C3)CC2.[H]Cl
Molecular Formula
C18H23ClN2O2
Molecular Weight
334.84
Precautions
H302, H315, H319, H335
References & Citations
[1]Chen, H. X. et al. Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist. PloS one 8, e83271, doi:10.1371/journal.pone.0083271 (2013) .|[2]Qin, J. J. et al. The role of activation of the 5-HT1A receptor and adenylate cyclase in the antidepressant-like effect of YL-0919, a dual 5-HT1A agonist and selective serotonin reuptake inhibitor. Neuroscience letters 582, 104-108, 2014.09.009 (2014)
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT1 Receptor; mLAG-3

Chemical Information

Hypidone (hydrochloride)
CAS Number1339058-04-6
PubChem CID122412736
IUPAC Name1-[(1-benzyl-4-hydroxypiperidin-4-yl)methyl]pyridin-2-one;hydrochloride
Molecular FormulaC18H23ClN2O2
Molecular Weight334.8
Topological Polar Surface Area43.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity444
SMILES
C1CN(CCC1(CN2C=CC=CC2=O)O)CC3=CC=CC=C3.Cl
InChI
InChI=1S/C18H22N2O2.ClH/c21-17-8-4-5-11-20(17)15-18(22)9-12-19(13-10-18)14-16-6-2-1-3-7-16;/h1-8,11,22H,9-10,12-15H2;1H
InChIKey
OXILSFMNCPZGAH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hypidone (hydrochloride)
CAS: 1339058-04-6
CID: 122412736
Formula: C18H23ClN2O2
MW: 334.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight334.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass334.1448057
Monoisotopic Mass334.1448057
Topological Polar Surface Area43.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity444
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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