(Rac) -SHIN2

CAT: 0804-HY-134978-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-134978-01Size:5 mg
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Description
(Rac) -SHIN2 is a pyrazolopyran derivative and a serine hydroxymethyltransferase (SHMT) inhibitor. (Rac) -SHIN2 has antibacterial activity and low cytotoxicity against Hep2 cells. (Rac) -SHIN2 exerts potent antibacterial activity against both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus[1][2].
CAS Number
[2204289-53-0]
UNSPSC
12352005
Target
Bacterial; SHMT
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rac-shin2.html
Purity
99.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC(C1(C2=CC(C#CCCCO)=CC(CO)=C2)C(C)C)=C(N)OC3=C1C(C)=NN3
Molecular Formula
C23H26N4O3
Molecular Weight
406.48
References & Citations
[1]Vamsi Mootha, et al. Method of treating and preventing viral infection. WO2022120195A1. 2022-06-09.|[2]Hayashi H, et al. SHIN-2 exerts potent activity against VanA-type vancomycin-resistant Enterococcus faecium in vitro by stabilizing the active site loop of serine hydroxymethyltransferase. Arch Biochem Biophys. 2024 Nov;761:110160.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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