(Rac) -SHIN2

• Description :

  (Rac) -SHIN2 is a pyrazolopyran derivative and a serine hydroxymethyltransferase (SHMT) inhibitor. (Rac) -SHIN2 has antibacterial activity and low cytotoxicity against Hep2 cells. (Rac) -SHIN2 exerts potent antibacterial activity against both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus[1][2].

• UNSPSC :

  12352005

• Target :

  Bacterial; SHMT

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/rac-shin2.html

• Purity :

  99.09

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  N#CC(C1(C2=CC(C#CCCCO)=CC(CO)=C2)C(C)C)=C(N)OC3=C1C(C)=NN3

• Molecular Formula :

  C23H26N4O3

• Molecular Weight :

  406.48

• References & Citations :

  [1]Vamsi Mootha, et al. Method of treating and preventing viral infection. WO2022120195A1. 2022-06-09.|[2]Hayashi H, et al. SHIN-2 exerts potent activity against VanA-type vancomycin-resistant Enterococcus faecium in vitro by stabilizing the active site loop of serine hydroxymethyltransferase. Arch Biochem Biophys. 2024 Nov;761:110160.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2204289-53-0]