(Rac) -SHIN2

• Description:

  (Rac) -SHIN2 is a pyrazolopyran derivative and a serine hydroxymethyltransferase (SHMT) inhibitor. (Rac) -SHIN2 has antibacterial activity and low cytotoxicity against Hep2 cells. (Rac) -SHIN2 exerts potent antibacterial activity against both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus[1][2].

• UNSPSC:

  12352005

• Target:

  Bacterial; SHMT

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/rac-shin2.html

• Purity:

  99.09

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  N#CC (C1 (C2=CC (C#CCCCO) =CC (CO) =C2) C (C) C) =C (N) OC3=C1C (C) =NN3

• Molecular Formula:

  C23H26N4O3

• Molecular Weight:

  406.48

• References & Citations:

  [1]Vamsi Mootha, et al. Method of treating and preventing viral infection. WO2022120195A1. 2022-06-09.|[2]Hayashi H, et al. SHIN-2 exerts potent activity against VanA-type vancomycin-resistant Enterococcus faecium in vitro by stabilizing the active site loop of serine hydroxymethyltransferase. Arch Biochem Biophys. 2024 Nov;761:110160.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2204289-53-0