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(Z) -SU5614

CAT: 0804-HY-18952A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18952A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Z) -SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1].
CAS Number
1055412-47-9
UNSPSC
12352005
Hazard Statement
H302, H413
Target
Apoptosis; FLT3
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-su5614.html
Purity
98.09
Solubility
DMSO : 13.89 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC2=C(C=C(Cl)C=C2)/C1=C/C3=C(C)C=C(C)N3
Molecular Formula
C15H13ClN2O
Molecular Weight
272.74
Precautions
H302, H413
References & Citations
[1]Spiekermann K, et al. The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood. 2003 Feb 15;101 (4) :1494-504.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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