Alisol B

• Description :

  Alisol B is a potential compound for researching orthopedic diseases, acting by influencing the differentiation of osteoclasts and their function.

• CAS Number :

  [18649-93-9]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Others

• Type :

  Natural Products

• Related Pathways :

  Others

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/Alisol-B.html

• Concentration :

  10mM

• Purity :

  99.57

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@]([C@@]1(C2=C([C@H](C)C[C@@H]([C@]3([H])C(C)(C)O3)O)CC1)C)(CC[C@@]4([H])C5(C)C)[C@]([C@H](C2)O)([H])[C@]4(CCC5=O)C

• Molecular Formula :

  C30H48O4

• Molecular Weight :

  472.70

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zhang RF, et al.[Alisol B inhibited complement 3a-induced human renal tubular epithelial to mesenchymal transition]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Oct;32 (10) :1407-12.|[2]Lee JW, et al. Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice. Biochem Pharmacol. 2010 Aug 1;80 (3) :352-61.|[3]Law BY, et al. Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca (2+) ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Mol Cancer Ther. 2010 Mar;9 (3) :718-30.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported