Alisol A

• Description:

  Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8) . Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity[1][2][3][4][5][6][7].

• UNSPSC:

  12352211

• Hazard Statement:

  H302

• Target:

  Acetyl-CoA Carboxylase; AMPK; Interleukin Related; MMP; PPAR

• Type:

  Natural Products

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer; Infection; Neurological Disease; Inflammation/Immunology; Cardiovascular Disease; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/Alisol-A.html

• Purity:

  99.50

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C[C@]([C@@]1(C2=C([C@H](C)C[C@H](O)[C@@H](O)C(C)(O)C)CC1)C)(CC[C@@]3([H])C4(C)C)[C@]([C@H](C2)O)([H])[C@]3(CCC4=O)C

• Molecular Formula:

  C30H50O5

• Molecular Weight:

  490.72

• Precautions:

  H302

• References & Citations:

  [1]Matsuda H, et al. Studies on Alismatis Rhizoma. II. Anti-complementary activities of methanol extract and terpene components from Alismatis Rhizoma (dried rhizome of Alisma orientale) . Biol Pharm Bull. 1998 Dec;21 (12) :1317-21.|[2]Zhang Q, et al. Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: a new class of hepatitis B virus inhibitors. Bioorg Med Chem Lett. 2008 Aug 15;18 (16) :4647-50.|[3]Lou C, et al. Alisol A Suppresses Proliferation, Migration, and Invasion in Human Breast Cancer MDA-MB-231 Cells. Molecules. 2019 Oct 10;24 (20) :3651.|[4]Ho C, et al. Alisol A attenuates high-fat-diet-induced obesity and metabolic disorders via the AMPK/ACC/SREBP-1c pathway. J Cell Mol Med. 2019 Aug;23 (8) :5108-5118.|[5]Ma Y, et al. Alisol A inhibits and stabilizes atherosclerotic plaques by protecting vascular endothelial cells. Front Pharmacol. 2024 Oct 25;15:1493948.|[6]Han W, et al. Alisol A attenuates malignant phenotypes of colorectal cancer cells by inactivating PI3K/Akt signaling. Oncol Lett. 2022 Jun 7;24 (2) :249.|[7]Wang K, et al. Alisol A Alleviates Arterial Plaque by Activating AMPK/SIRT1 Signaling Pathway in apoE-Deficient Mice. Front Pharmacol. 2020 Nov 2;11:580073.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  IL-1; IL-6; IL-8; MMP-2; MMP-9; PPARα

• CAS Number:

  19885-10-0