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I194496

CAT: 0804-HY-169212-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169212-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
I194496 is a potent cystathionine γ-lyase (CSE) inhibitor, with an IC50 of 0.79 mM. I194496 can inhibit the growth of human TNBC cells via the dual targeting PI3K/Akt and Ras/Raf/ERK pathway and suppress the metastasis of human TNBC cells via down-regulating Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways[1].
CAS Number
445238-07-3
UNSPSC
12352005
Target
Akt; Annexin A; ERK; FAK; PI3K; Raf; Ras; STAT; VEGFR
Type
Reference compound
Related Pathways
Cytoskeleton; GPCR/G Protein; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/i194496.html
Purity
98.52
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(N=C(C2=CC=C(OC)C=C2)C=C3C(F)F)N3N=C1)NC4=CC=C(S(=O)(NC5=C(OC)C=CC=C5)=O)C=C4
Molecular Formula
C28H23F2N5O5S
Molecular Weight
579.57
References & Citations
[1]Liu Y, et al. A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways. Sci Rep. 2021 Apr 26;11 (1) :8963.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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