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MCL0020

CAT: 0804-HY-107627-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107627-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].
CAS Number
475498-26-1
UNSPSC
12352209
Hazard Statement
H302, H315, H319
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mcl0020.html
Purity
99.93
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC([C@H](CC1=CC2=C(C=CC=C2)C=C1)NC([C@H](CCCNC(N)=N)NC([C@H](NC(C)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)=O)=O
Molecular Formula
C34H39N7O4
Molecular Weight
609.72
Precautions
H302, H315, H319
References & Citations
[1]Chaki S, et al. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003;474 (1) :95-101.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC4R

Chemical Information

Ac-D-2Nal-Arg-D-2Nal-NH2
CAS Number475498-26-1
PubChem CID9938789
IUPAC Name(2S)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-N-[(2R)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
Molecular FormulaC34H39N7O4
Molecular Weight609.7
XLogP2.9
Topological Polar Surface Area195
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count5
Rotatable Bond Count14
Heavy Atom Count45
Formal Charge0
Complexity1050
SMILES
CC(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CC3=CC4=CC=CC=C4C=C3)C(=O)N
InChI
InChI=1S/C34H39N7O4/c1-21(42)39-30(20-23-13-15-25-8-3-5-10-27(25)18-23)33(45)40-28(11-6-16-38-34(36)37)32(44)41-29(31(35)43)19-22-12-14-24-7-2-4-9-26(24)17-22/h2-5,7-10,12-15,17-18,28-30H,6,11,16,19-20H2,1H3,(H2,35,43)(H,39,42)(H,40,45)(H,41,44)(H4,36,37,38)/t28-,29+,30+/m0/s1
InChIKey
FJFLYSMWSRRMRO-FRXPANAUSA-N
Chemical Structure
2D Structure
2D structure of Ac-D-2Nal-Arg-D-2Nal-NH2
CAS: 475498-26-1
CID: 9938789
Formula: C34H39N7O4
MW: 609.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight609.7
XLogP32.9
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count5
Rotatable Bond Count14
Exact Mass609.30635275
Monoisotopic Mass609.30635275
Topological Polar Surface Area195 Ų
Heavy Atom Count45
Formal Charge0
Complexity1050
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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