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CCMI

CAT: 0804-HY-12150-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12150-01Size:5 mg
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Description
CCMI (AVL-3288) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].
CAS Number
917837-54-8
Product Name Alternative
AVL-3288; UCI-4083
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ccmi.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(Cl)C=C1)/C(C2=CC(C)=NO2)=C/NC3=CC=C(Cl)C=C3
Molecular Formula
C19H15Cl2N3O2
Molecular Weight
388.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 8;104 (19) :8059-64. Epub 2007 Apr 30.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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