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4-Hydroxytolbutamide-d9

CAT: 0804-HY-100641SSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100641SSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].
CAS Number
1185112-19-9
Product Name Alternative
Hydroxytolbutamide-d9
UNSPSC
12352005
Hazard Statement
H225, H302+H312+H332, H319
Target
Autophagy; Potassium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Field of Research
Cancer; Metabolic Disease
Purity
99.29
Solubility
Ethanol : 12 mg/mL (ultrasonic; warming)
Smiles
O=S(C1=CC=C(CO)C=C1)(NC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=O
Molecular Formula
C12H9D9N2O4S
Molecular Weight
295.40
Precautions
H225, H302+H312+H332, H319
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2] Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21 (6) :664-71.|[3]Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30 (12) :1311-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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H9117-95CHydroxytolbutamide-d9 (N- (Butylamnocarbonyl) -4-hydroxymethylbenzenesulfonamide-d9)
MBS6044881-01Hydroxytolbutamide-d9 (N-(Butylamnocarbonyl)-4-hydroxymethylbenzenesulfonamide-d9)
T14040-014-Hydroxytolbutamide
H9117-95AHydroxytolbutamide (N- (Butylamnocarbonyl) -4-hydroxymethylbenzenesulfonamide)
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