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4-Hydroxytolbutamide

CAT: 0804-HY-100641-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100641-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].
CAS Number
5719-85-7
Product Name Alternative
Hydroxytolbutamide
UNSPSC
12352005
Hazard Statement
H225, H302+H312+H332, H319
Target
Autophagy; Potassium Channel
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/4-hydroxytolbutamide.html
Purity
99.69
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(CO)C=C1)(NC(NCCCC)=O)=O
Molecular Formula
C12H18N2O4S
Molecular Weight
286.35
Precautions
H225, H302+H312+H332, H319
References & Citations
[1] Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21 (6) :664-71.|[2]Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30 (12) :1311-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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