Products for Research Use Only
RegisterLogin

PF 05089771

CAT: 0804-HY-12883-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-12883-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PF 05089771 is a potent, orally active and selective arylsulfonamide Nav1.7 inhibitor, with IC50 values of 11 nM, 12 nM, 13 nM, 171 nM and 8 nM for hNav1.7, cynNav1.7, dogNav1.7, ratNav1.7, and musNav1.7, respectively. PF 05089771 is under the study for pain and diabetic neuropathy[1][2].
CAS Number
1235403-62-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PF-05089771.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(Cl)=C(OC2=CC=C(Cl)C=C2C3=CNN=C3N)C=C1F)(NC4=CSC=N4)=O
Molecular Formula
C18H12Cl2FN5O3S2
Molecular Weight
500.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Alexandrou AJ, et al. Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release. PLoS One. 2016 Apr 6;11 (4) :e0152405.|[2]Theile JW, et al. The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels. Mol Pharmacol. 2016 Nov;90 (5) :540-548.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Nav1.7

Related Products

CatalogName
HY-P990649-01PF-5212374
HY-111965-01PF-06647263
HY-10459-01PF-562271
HY-108341-01PF-06424439
HY-100398-01PF-04979064
HY-131972-01PF-06843195
HY-14464-01PF-00489791
HY-121163-01PF-184563
HY-124947PF-4522654
HY-116524PF-04781340

Alternative Products

CatalogName
MBS3841609-01PF-05089771
BUP02459-01PF 05089771
526590PF-05089771 Tosylate
A16365-10PF-05089771 10mg
A16365-5PF-05089771 5mg
GTR19184175-01PF 05089771 tosylate
A16365-100PF-05089771 100mg
5931/50PF 05089771 50 mg
M10943-01PF-05089771 free base
A16365-50PF-05089771 50mg

Popular Products