Products for Research Use Only
RegisterLogin

SX-517

CAT: 0804-HY-12927-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-12927-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca2+ flux (IC50=38 nM), and antagonizes CXCL8-induced [ (35) S]GTPγS binding (IC50=60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for inflammation suppression, in both humanized polymorphonuclear (PMN) cells and in murine model[1][2].
CAS Number
1240494-13-6
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sx-517.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OB(C1=CC=CC=C1CSC2=NC=C(C(NC3=CC=C(F)C=C3)=O)C=C2)O
Molecular Formula
C19H16BFN2O3S
Molecular Weight
382.22
References & Citations
[1]2-[5- (4-Fluorophenylcarbamoyl) pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517) : Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2. J Med Chem. 2014 Oct 23;57 (20) :8378-97. |[2]Ti H, et al. Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs) . J Med Chem. 2019 Jul 11;62 (13) :5944-5978.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR1; CXCR2

Related Products

CatalogName
HY-100291SX-3228
HY-119339-01SX-682
HY-108646-01SX 011
HY-156682-01JNT-517
HY-P5336μ-Conotoxin Sx IIIA
HY-10634-01AMG 517
HY-W952988CRBN ligand-517
HY-10634RAMG 517 (Standard)
HY-R01557A-01Hsa-miR-517-5p agomir
HY-RI01557A-01Hsa-miR-517-5p antagomir

Alternative Products

CatalogName
BA5301-5SX-517
BA5289-100SX-682
JMA91342-01SX 011
T70579-01SX 3202
MBS5767679SX-3228
MBS5813693SX-576
574884SX-011

Popular Products