SX-517

CAT: 0931-T28893-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0931-T28893-01Size:5 mg

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PRICE

AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

1 / 1

CAS Number

1240494-13-6

Target

CXCR

Related Pathways

GPCR/G Protein|||Immunology/Inflammation|||Autophagy

Bioactivity

SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca²? flux (IC?? = 38 nM), antagonises CXCL-8-induced [ (³?) S]GTP?S binding (IC?? = 60 nM), and suppresses ERK1/2 phosphorylation.

Smiles

O=C(NC1=CC=C(F)C=C1)C2=CN=C(SCC=3C=CC=CC3B(O)O)C=C2

Molecular Formula

C19H16BFN2O3S

Molecular Weight

382.22

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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SX-517

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