SX-517

• Target:

  CXCR

• Related Pathways:

  GPCR/G Protein|||Immunology/Inflammation|||Autophagy

• Bioactivity:

  SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca²? flux (IC?? = 38 nM), antagonises CXCL-8-induced [ (³?) S]GTP?S binding (IC?? = 60 nM), and suppresses ERK1/2 phosphorylation.

• Smiles:

  O=C(NC1=CC=C(F)C=C1)C2=CN=C(SCC=3C=CC=CC3B(O)O)C=C2

• Molecular Formula:

  C19H16BFN2O3S

• Molecular Weight:

  382.22

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1240494-13-6