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SX-517

CAT: 931-T28893-01Size: 5 mgDry Ice: NoHazardous: No
5 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
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CAS Number
1240494-13-6
Target
CXCR
Related Pathways
GPCR/G Protein|||Immunology/Inflammation|||Autophagy
Bioactivity
SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca²? flux (IC?? = 38 nM), antagonises CXCL-8-induced [ (³?) S]GTP?S binding (IC?? = 60 nM), and suppresses ERK1/2 phosphorylation.
Smiles
O=C(NC1=CC=C(F)C=C1)C2=CN=C(SCC=3C=CC=CC3B(O)O)C=C2
Molecular Formula
C19H16BFN2O3S
Molecular Weight
382.22
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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