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XRP44X

CAT: 0804-HY-107753-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107753-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XRP44X inhibits Ras-induced transcription activation with the IC50 of 10 nM. XRP44X inhibits activation of the Ras-Erk-1/2 pathway by FGF-2[1]. XRP44X is an inhibitor of Ras/Erk activation of Elk3 that also affects microtubules[2].
CAS Number
729605-21-4
UNSPSC
12352005
Hazard Statement
H301
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/xrp44x.html
Purity
98.09
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(C2=CC(Cl)=CC=C2)CC1)C3=CC(C)=NN3C4=CC=CC=C4
Molecular Formula
C21H21ClN4O
Molecular Weight
380.87
Precautions
H301
References & Citations
[1]Christine Wasylyk, et al. Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. Cancer Res. 2008 Mar 1;68 (5) :1275-83.|[2]Kostyantyn Semenchenko, et al. XRP44X, an Inhibitor of Ras/Erk Activation of the Transcription Factor Elk3, Inhibits Tumour Growth and Metastasis in Mice. PLoS One. 2016 Jul 18;11 (7) :e0159531.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Ras

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TRC-X750960-50MGXRP44X
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A16049-25XRP44X 25mg
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