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Strophanthidin

CAT: 0804-HY-114252-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114252-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Strophanthidin is a naturally available cardiac glycoside[1]. Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal[2]. Strophanthidin increases both diastolic and systolic intracellular Ca2+ concentration[3].
CAS Number
66-28-4
Product Name Alternative
Splitomycin, Erythromycin Cyclocarbonate
UNSPSC
12352005
Hazard Statement
H300+H310+H330
Target
Na+/K+ ATPase
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/strophanthidin.html
Purity
98.53
Solubility
Ethanol : 25 mg/mL (ultrasonic)
Smiles
O=C[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@@H](O)CC2)O)([H])[C@@]4([C@@](C)([C@@H](C5=CC(OC5)=O)CC4)CC3)O
Molecular Formula
C23H32O6
Molecular Weight
404.50
Precautions
H300+H310+H330
References & Citations
[1]Reddy D, et al. Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers. Front Oncol. 2020;9:1469. Published 2020 Jan 17.|[2]Su SW, et al. Relationship between cardiotonic effects and inhibition on cardiac sarcolemmal Na+, K+-ATPase of strophan-thidin at low concentrations. Acta Pharmacol Sin. 2003;24 (11) :1103-1107.|[3]Bennett DL, et al. Strophanthidin-induced gain of Ca2+ occurs during diastole and not systole in guinea-pig ventricular myocytes. Pflugers Arch. 1999;437 (5) :731-736.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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