Devimistat

• Description:

  Devimistat is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H410

• Target:

  Apoptosis; Mitochondrial Metabolism

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CPI-613.html

• Concentration:

  10mM

• Purity:

  99.59

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(O)CCCCC(SCC1=CC=CC=C1)CCSCC2=CC=CC=C2

• Molecular Formula:

  C22H28O2S2

• Molecular Weight:

  388.59

• Precautions:

  H410

• References & Citations:

  [1]Sakuratani T, et al. Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway. Virchows Arch. 2021;478 (3) :401-411.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 3

• CAS Number:

  [95809-78-2]