EGFR T790M/L858R-IN-8

• UNSPSC Description:

  EGFR T790M/L858R-IN-8 (compound 9) is a potent inhibitor of EGFR, targeting mutant EGFRT790M/L858R with IC50 of 56.8 μM. The anti-proliferative effect of EGFR T790M/L858R-IN-8 on cancer cell lines A549, A431, and NHI-H1975 is not significant[1].

• Target Antigen:

  EGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/egfr-t790m-l858r-in-8.html

• Solubility:

  DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(C1=C(O)C2=C(C=CC=C2)NC1=O)NC3=CC(Br)=CC=C3

• Molecular Weight:

  359.17

• References & Citations:

  [1]Bai F, et al. Discovery of novel selective inhibitors for EGFR-T790M/L858R. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1365-70.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  333419-97-9