Amitriptyline (hydrochloride) (Standard)

Amitriptyline hydrochloride (Standard) is the analytical standard of Amitriptyline hydrochloride. This product is intended for research and analytical applications. Amitriptyline hydrochloride is an orally active tricyclic antidepressant (TCA). Amitriptyline hydrochloride mainly exerts its antidepressant effect by blocking SERT (Ki = 3.45 nM) and NET (Ki = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline hydrochloride is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline hydrochloride can reduce inflammation, angiogenesis and fibrosis. Amitriptyline hydrochloride binds to DAT (with Ki = 2.58 μM). Amitriptyline hydrochloride has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (Ki = 11-24 nM), H1 receptors (Ki = 0.5-1.1 nM), adrenergic α1 receptors (Ki = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline hydrochloride can block sodium channels and hERG potassium channel (IC50 = 4.78 μM) and it has cardiotoxicity.

549-18-8

12352005

H301, H319, H410

5-HT Receptor; Adrenergic Receptor; Apoptosis; Dopamine Transporter; Histamine Receptor; mAChR; Potassium Channel; Reference Standards; Serotonin Transporter; Sodium Channel; Trk Receptor

Reference Standards

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Others; Protein Tyrosine Kinase/RTK

Endocrinology; Inflammation/Immunology; Neurological Disease

https://www.medchemexpress.com/amitriptyline-hydrochloride-standard.html

99.03

CN(C)CC/C=C1C2=CC=CC=C2CCC3=C\1C=CC=C3.Cl

C20H24ClN

313.86

H301, H319, H410

Room Temperature

4°C, sealed storage, away from light and moisture

Reference Standards

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