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Deoxycorticosterone acetate

CAT: 0804-HY-B1472-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1472-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria[1][2].
CAS Number
56-47-3
Product Name Alternative
11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate
UNSPSC
12352211
Hazard Statement
H360, H373
Target
Endogenous Metabolite; Mineralocorticoid Receptor
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Deoxycorticosterone-acetate.html
Purity
99.87
Solubility
DMSO : 16.67 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
C[C@@]12[C@@H](C(COC(C)=O)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O
Molecular Formula
C23H32O4
Molecular Weight
372.50
Precautions
H360, H373
References & Citations
[1]Lu NZ, et al. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol Rev. 2006 Dec;58 (4) :782-97. |[2]Lother A, et al. Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure. Hypertension. 2016 Jan;67 (1) :130-8. |[3]M J Somers, et al. Vascular Superoxide Production and Vasomotor Function in Hypertension Induced by Deoxycorticosterone Acetate–Salt. Circulation. 2000 Apr 11;101 (14) :1722-8.|[4]Y Matsumura, et al. Different Contributions of Endothelin-A and Endothelin-B Receptors in the Pathogenesis of Deoxycorticosterone Acetate–Salt–Induced Hypertension in Rats. Hypertension. 1999 Feb;33 (2) :759-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

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