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Deoxycorticosterone

CAT: 0804-HY-113414-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113414-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. Deoxycorticosterone is an agonist for O. mykiss mineralocorticoid receptor (rtMR) transcription with EC50 of 0.16 nM[3]. Deoxycorticosterone could acts as an immune stimulator in fish[4].
CAS Number
64-85-7
UNSPSC
12352211
Hazard Statement
H351, H373
Target
Endogenous Metabolite; Mineralocorticoid Receptor
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/Deoxycorticosterone.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O
Molecular Formula
C21H30O3
Molecular Weight
330.46
Precautions
H351, H373
References & Citations
[1]KAGAWA CM, et al. Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt. Science. 1957 Nov 15;126 (3281) :1015-6.|[2]Milla S, et al., Plasma 11-deoxycorticosterone (DOC) and mineralocorticoid receptor testicular expression during rainbow trout Oncorhynchus mykiss spermiation: implication with 17alpha, 20beta-dihydroxyprogesterone on the milt fluidity? Reprod Biol Endocrinol. 2008 May 19;6:19.|[3]Sturm A, et al., 11-deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor. Endocrinology. 2005 Jan;146 (1) :47-55.|[4]Mathieu C, et al., First evidence of the possible implication of the 11-deoxycorticosterone (DOC) in immune activity of Eurasian perch (Perca fluviatilis, L.) : comparison with cortisol. Comp Biochem Physiol A Mol Integr Physiol. 2013 Jun;165 (2) :149-58.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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