2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP

• UNSPSC Description:

  2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP is an E3 Ligase ligand-linker conjugate, and can be used for synthesis of PROTAC SOS1 degrader-10 (HY-161654)[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2-methoxyphenyl-dihydrouracil-azaspiro-5-5-undecane-c-pip.html

• Smiles:

  O=C(N1CCC(CC2)(CC1)CCC2CN3CCNCC3)C4=CC=C(OC)C(N5CCC(NC5=O)=O)=C4

• Molecular Weight:

  497.63

• References & Citations:

  [1]Wang K, et al. Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido[2,3-d]pyrimidin-7-one-based SOS1 inhibitor. Bioorg Med Chem Lett. 2024 Jul 15;107:129780.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported