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WK88-1

CAT: 0804-HY-164548Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164548Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WK88-1, a Hsp90 inhibitor, induces overall degradation of multiple oncogenic signaling molecules including EGFR, ErbB2 and ErbB3, leading to subsequent growth arrest and apoptosis in the Gefitinib-resistant H1975 cell line[1].
CAS Number
958888-32-9
UNSPSC
12352005
Target
Apoptosis; HSP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wk88-1.html
Smiles
C/C(C(NC1=CC2=CC=C1)=O)=C/CC[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]([C@@H](OC)C[C@@H](C2)C)O
Molecular Formula
C28H42N2O6
Molecular Weight
502.64
References & Citations
[1]Young-Soo Hong, et al. Hsp90 inhibition by WK88-1 potently suppresses the growth of gefitinib-resistant H1975 cells harboring the T790M mutation in EGFR. Oncol Rep. 2014 Jun;31 (6) :2619-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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