Products for Research Use Only
RegisterLogin

Monactin

CAT: 0804-HY-111525Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-111525Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].
CAS Number
7182-54-9
UNSPSC
12352005
Target
Antibiotic; Bacterial; Oxidative Phosphorylation
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/monactin.html
Solubility
10 mM in DMSO
Smiles
CC[C@@H](OC([C@@H]([C@H]1O[C@@](C[C@@H](OC([C@H]([C@@](CC2)([H])O[C@@]2([H])C3)C)=O)C)([H])CC1)C)=O)C[C@]4([H])O[C@@]([C@@H](C(O[C@H](C[C@@]5([H])O[C@H]([C@H](C(O[C@@H]3C)=O)C)CC5)C)=O)C)([H])CC4
Molecular Formula
C41H66O12
Molecular Weight
750.96
References & Citations
[1]Graven SN, et al. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Biochemistry. 1966;5 (5) :1735-1742.|[2]Murer H, et al. On the mechanism of sugar and amino acid interaction in intestinal transport. J Biol Chem. 1975;250 (18) :7392-7396.|[3]Harinantenaina Rakotondraibe L, et al. Antiproliferative and antiplasmodial compounds from selected Streptomyces species. Bioorg Med Chem Lett. 2015;25 (23) :5646-5649.|[4]Tamai, Y, et al. Nonactin and related compounds found in a screening program for wnt signal inhibitory activity. Heterocycles, 84 (2), 1245-1250.|[5]Harold FM, et al. Effects of nigericin and monactin on cation permeability of Streptococcus faecalis and metabolic capacities of potassium-depleted cells. J Bacteriol. 1968;95 (3) :816-823.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-N6641-01Monascin
HY-N12534Monaspin B
HY-104051-01Monacolin J
HY-N6641RMonascin (Standard)

Alternative Products

CatalogName
M065-1MGMonactin
N648968Nonactin (Mixture contains Monactin and Dinactin) (Technical Grade)
M4431Monactin (5-demethyl-5-ethylnonactin, Antibiotic AKD 1B)

Popular Products