Cefazolin

CAT: 0804-HY-B1892-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-B1892-02Size:10 mM - 1 mL

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Cefazolin (Cephazolin) is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD) [2].

CAS Number

25953-19-9

Product Name Alternative

Cephazolin

UNSPSC

12352005

Hazard Statement

H317, H334

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/cefazolin.html

Purity

99.73

Solubility

DMSO : 140 mg/mL (ultrasonic)

Smiles

O=C(C(N12)=C(CSC3=NN=C(C)S3)CS[C@]2([H])[C@H](NC(CN4N=NN=C4)=O)C1=O)O

Molecular Formula

C14H14N8O4S3

Molecular Weight

454.51

Precautions

H317, H334

References & Citations

[1]R Quintiliani, et al. Cefazolin. Ann Intern Med. 1978 Nov;89 (5 Pt 1) :650-6.|[2]Peng Liang, et al. Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice. J Neuroinflammation. 2018 Aug 22;15 (1) :235.|[3]Barbara Żyżyńska-Granica, et al. The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor. Sci Rep. 2020 Feb 19;10 (1) :2886.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

β-lactam

Citation 01

Chemical Information

Cefazolin

Cefazolin is a first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively. It has a role as an antibacterial drug. It is a cephalosporin, a member of tetrazoles, a member of thiadiazoles and a beta-lactam antibiotic allergen. It is a conjugate acid of a cefazolin(1-).

CAS Number	25953-19-9
PubChem CID	33255
IUPAC Name	(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Molecular Formula	C14H14N8O4S3
Molecular Weight	454.5
XLogP	-0.4
Topological Polar Surface Area	235
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	7
Heavy Atom Count	29
Formal Charge	0
Complexity	740

SMILES

CC1=NN=C(S1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)O

InChI

InChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1

InChIKey

MLYYVTUWGNIJIB-BXKDBHETSA-N

Chemical Structure

2D Structure

CAS: 25953-19-9

CID: 33255

Formula: C14H14N8O4S3

MW: 454.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	454.5
XLogP3	-0.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	7
Exact Mass	454.03001448
Monoisotopic Mass	454.03001448
Topological Polar Surface Area	235 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	740
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
TRC-C242495-10G	Cefazolin
RM-C062721-01	Cefazolin EP Impurity L; Cefazolin Epimer
MBS3841669-01	Cefazolin Sodium

Cefazolin

Chemical Information

Alternative Products

Popular Products