Cefazolin

• UNSPSC Description:

  Cefazolin (Cephazolin) is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2].

• Target Antigen:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology; Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cefazolin.html

• Purity:

  99.76

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(C(N12)=C(CSC3=NN=C(C)S3)CS[C@]2([H])[C@H](NC(CN4N=NN=C4)=O)C1=O)O

• Molecular Weight:

  454.51

• References & Citations:

  [1]R Quintiliani, et al. Cefazolin. Ann Intern Med. 1978 Nov;89(5 Pt 1):650-6.|[2]Peng Liang, et al. Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice. J Neuroinflammation. 2018 Aug 22;15(1):235.|[3]Barbara Żyżyńska-Granica, et al. The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor. Sci Rep. 2020 Feb 19;10(1):2886.bioRxiv. 2024 May 10.|mSystems. 2023 Dec 4:e0102623.|Nat Commun. 2022 Mar 2;13(1):1116.|ACS Omega. March 3, 2022.|Emerg Microbes Infect. 2024 Dec;13(1):2321981.|Front Aging Neurosci. 2021 Oct 13;13:748637.|iScience. 5 January 2022, 103731.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  25953-19-9