Cefazolin

• Description:

  Cefazolin (Cephazolin) is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD) [2].

• Product Name Alternative:

  Cephazolin

• UNSPSC:

  12352005

• Hazard Statement:

  H317, H334

• Target:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology; Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cefazolin.html

• Purity:

  99.73

• Solubility:

  DMSO : 140 mg/mL (ultrasonic)

• Smiles:

  O=C(C(N12)=C(CSC3=NN=C(C)S3)CS[C@]2([H])[C@H](NC(CN4N=NN=C4)=O)C1=O)O

• Molecular Formula:

  C14H14N8O4S3

• Molecular Weight:

  454.51

• Precautions:

  H317, H334

• References & Citations:

  [1]R Quintiliani, et al. Cefazolin. Ann Intern Med. 1978 Nov;89 (5 Pt 1) :650-6.|[2]Peng Liang, et al. Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice. J Neuroinflammation. 2018 Aug 22;15 (1) :235.|[3]Barbara Żyżyńska-Granica, et al. The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor. Sci Rep. 2020 Feb 19;10 (1) :2886.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  β-lactam

• Citation 01:

  ACS Environ Au. 2025 Aug 8.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|bioRxiv. 2024 May 10.|Diagn Microbiol Infect Dis. 2025 Nov 4;114 (2) :117181.|mSystems. 2023 Dec 21;8 (6) :e0102623.|Nat Commun. 2022 Mar 2;13 (1) :1116.|ACS Omega. 2022 Mar 3;7 (10) :9004-9014.|Emerg Microbes Infect. 2024 Dec;13 (1) :2321981.|Front Aging Neurosci. 2021 Oct 13;13:748637.|iScience. 2022 Jan 5;25 (2) :103731.

• CAS Number:

  [25953-19-9]