HEK293/Human GIPR Stable Cell Line (High Expression)

HEK293/Human GIPR Stable Cell Line (High Expression)

• Background: This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
• Description: This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
• Host: HEK 293
• Origin Species: Human
• Target: GIPR
• Applications: Useful for cell-based GIPR binding assay Screen for human GIPR agonists based on cAMP accumulation assay
• Format: Liquid
• Shipping Conditions: Dry ice
• Storage Conditions: Frozen in liquid nitrogen