10-Cl-BBQ

10-Cl-BBQ

• Product Name Alternative: alpha-MCPG
• CAS Number: 23982-76-5
• UNSPSC Description: 10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations[1][2].
• Target Antigen: Aryl Hydrocarbon Receptor
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/10-cl-bbq.html
• Purity: 99.48
• Solubility: DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(N1C2=NC3=CC=C(C=C31)Cl)C4=CC=CC5=CC=CC2=C45
• Molecular Weight: 304.73
• References & Citations: [1]Allison K Ehrlich, et al. Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice. J Immunol. 2016 Jan 1;196(1):264-73.|[2]Sumit Punj, et al. Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One. 2014 Feb 19;9(2):e88726.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported