Sinapine (hydroxide)

• Description:

  Sinapine hydroxide is an alkaloid isolated from seeds of the cruciferous species. Sinapine hydroxide exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine hydroxide is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[1][2][3][4].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE) ; P-glycoprotein

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/sinapine-hydroxide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OCC[N+](C)(C)C)/C=C/C(C=C1OC)=CC(OC)=C1O.[OH-]

• Molecular Formula:

  C16H25NO6

• Molecular Weight:

  327.37

• References & Citations:

  [1]Boulghobra D, et, al. Sinapine, but not sinapic acid, counteracts mitochondrial oxidative stress in cardiomyocytes. Redox Biol. 2020 Jul;34:101554.|[2]Li Y, et, al. Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota. Food Funct. 2019 Jun 19;10 (6) :3637-3649.|[3]Guo Y, et, al. Sinapine as an active compound for inhibiting the proliferation of Caco-2 cells via downregulation of P-glycoprotein. Food Chem Toxicol. 2014 May;67:187-92.|[4]Yates K, et, al. Determination of sinapine in rapeseed pomace extract: Its antioxidant and acetylcholinesterase inhibition properties. Food Chem. 2019 Mar 15;276:768-775.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  AChE

• CAS Number:

  [122-30-5]