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Dynamin IN-2

CAT: 0804-HY-152216-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-152216-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dynamin IN-2 (compound 43), a Wiskostatin analogue, is a potent dynamin inhibitor, with an IC50 of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated endocytosis (CME), with an IC50 of 9.5 μM[1].
CAS Number
1345853-49-7
UNSPSC
12352005
Target
Dynamin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dynamin-in-2.html
Purity
98.93
Solubility
10 mM in DMSO
Smiles
ClC(C=C1)=CC=C1CNCC(CN2C3=CC=CC=C3C4=CC=CC=C42)O
Molecular Formula
C22H21ClN2O
Molecular Weight
364.87
References & Citations
[1]Cossar PJ, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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