Products for Research Use Only
RegisterLogin

SG3199

CAT: 0804-HY-101161-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101161-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) [1][2].
CAS Number
1595275-71-0
UNSPSC
12352203
Target
ADC Payload; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sg3199.html
Purity
98.94
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
O=C1N2[C@](CC(C)=C2)([H])C=NC3=CC(OCCCCCOC4=C(OC)C=C5C(N6[C@](CC(C)=C6)([H])C=NC5=C4)=O)=C(OC)C=C13
Molecular Formula
C33H36N4O6
Molecular Weight
584.66
References & Citations
[1]John A Hartley, et al. Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine. Sci Rep. 2018 Jul 11;8 (1) :10479.|[2]Francesca Zammarchi, et al. ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies. Blood. 2018 Mar 8;131 (10) :1094-1105.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Pyrrolobenzodiazepines

Related Products

CatalogName
HY-168507SG31

Alternative Products

CatalogName
T34628SG3199
GTR19231406-01SG3199-Val-Ala-PAB
T87879-01BCN-HS-PEG2-VA-PABC-SG3199
GTR19264634-01DBCO-HS-PEG2-VA-PABC-SG3199
T87853-01Mal-amido-PEG8-Val-Ala-PAB-SG3199

Popular Products