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AF3485

CAT: 0804-HY-118184-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118184-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AF3485 is a human mPGES-1 inhibitor that exhibits antitumor activity in vitro and in vivo. AF3485 inhibits tumor-associated angiogenesis by reducing PGE2 production, inhibiting EGFR signaling, and decreasing VEGF and FGF-2 expression. AF3485 reduced tumor growth in mice bearing human A431 xenograft tumors by subchronic administration.
CAS Number
1195786-61-8
UNSPSC
12352005
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/af3485.html
Smiles
OCCN(C1=C2C=C(C=C1)NC(C3=CC=CC=C3C(F)(F)F)=O)C4=C2C=CC=C4
Molecular Formula
C22H17F3N2O2
Molecular Weight
398.38
References & Citations
[1]Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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